Domanassa vedana could arise when someone is depressed by a kayika vedana (due to avijja). Of course, the kayika vedana is a kamma vipaka.
– By the way, karma is a Sanskrit word. We should try to use Pali words like kamma and Nibbana (instead of nirvana). I know that we are so used to using these Sanskrit words.
Another way to look at this is that ALL factors of akusala-mula Paticca Samuppada are eliminated at the Arahant stage.
– However, those are just the factors in the “niddesa” version above.
– For example, “smphassa-ja-vedana” will not arise in Arahant. But kayika vedana (sukha or dukkha) will arise until Parinibbana (death of the Arahant).
Your friend should start learning Dhamma. That is the way to reduce avijja and gradually reduce smphassa-ja-vedana.