Inflib (Donna) said: “As one proceeds on the Path and comprehends, acts, speaks and thinks with the anicca (dukkha and anatta as well) nature, will it effect the kamma vipaka experienced in day-to-day life?”.
You may want to read the post, “What is Kamma? – Is Everything Determined by Kamma?“.
Basically, some vipaka can be overcome, but not all. Even the Buddha could not overcome some. We had discussed this before, but I cannot locate that particular discussion.
Nibbana is about totally eliminating FUTURE suffering beyond this life: A Sotapanna would not be reborn in the apayas; a Sakadagami would not be reborn at or below human realm; An Anagami would be prevented from suffering in kama loka, so will not be reborn in kama loka; an Arahant will not be reborn anywhere in 31 realms. Any birth anywhere in the 31 realm will be subjected to suffering at some level.
A type of suffering that goes away completely for an Arahant in this life is those due to “samphassa ja vedana” (self-induced MENTAL suffering). It will be removed partially for other Nobles depending on how much “san” or defilements have been removed from their minds; see, “Vēdanā (Feelings) Arise in Two Ways“. Even before magga phala, this could give rise to “niramisa sukha” at various levels.
If this does not explain, we can discuss any more remaining issues.