“Things” or “events” in this world arise due to six root causes (lobha, dosa, moha, alobha, adosa, amoha).
– Lobha, dosa, moha lead to rebirths in the apayas (four lowest realms).
– Alobha, adosa, amoha lead to rebirths in human and higher realms.
– All those perpetuate sansaric journey (rebirth process), and thus binds one to suffering filled “this world of 31 realms”.
Those are the causes. When those causes are removed nothing in this can arise, and one attains Nibbana.
There are no causes for Nibbana. That is why it is called asankata.
– Nibbana RESULTS when all six causes are removed by cultivating panna, i.e., by comprehending the true nature of this world.
Cultivation of panna is not a cause. It is the Path to Nibbaba (via removing all six root causes).