I do not pretend to be able to clarify, but to at least give more substance to the question, in order that any answer may be more comprehensive. I hope it is relevant. Thus:
In English at least, we take space to mean that which contains, the Infinite Container, to put it that way. Now ‘dhatu’ already implies matter ,in however fine a form (space ELEMENT)so it too will be contained. So a difference there must be.
Also, Infinite Space cannot be, strictly-speaking, a container, because all containers are limited in their outer dimensions, hence they can contain within those dimensions. But Infinite Space has no such limits. Another word or term will have to be coined, if it hasn’t been aleady.
By extrapolation, even Nibbana will lie within that Infinite Space, for Infinity, by definition, means that there can be nothing beyond it.
y not